The most common use is dropping the acapella over a completely new instrumental. Because the original track is at 126 BPM (4/4 time signature), the acapella is incredibly flexible. It works at 100 BPM for a future bass remix, 128 BPM for big room house, or even 70 BPM for a melodic dubstep halftime edit. The lyrical theme of resilience fits almost any genre.
A note of caution. Searching for the often leads to shady YouTube converters or file-sharing forums. While it is tempting to grab a free MP3, the official acapella is copyrighted material owned by What A Music Ltd, Parlophone, and Capitol Records.
Digital DJs using CDJs or controllers with STEM separation (like the Pioneer DJM-V10 or rekordbox 6) often use the high-quality studio acapella to inject a singalong moment into a techno or tech-house set. There is no faster way to get a crowd raising their hands than cutting the bass, dropping the Titanium vocal acapella, and watching the audience scream "FIRE AWAY!"
