Tribulus Terrestris Monograph

Let us separate the gym-bro lore from the peer-reviewed literature.

In rodents, the LD50 of aqueous extract is >5000 mg/kg (low toxicity). Subchronic (90-day) studies in rats at doses up to 2000 mg/kg/day showed no significant hematological, hepatic, or renal toxicity. tribulus terrestris monograph

These are the primary active constituents responsible for the plant’s biological effects. The aglycone (non-sugar) portion of these saponins is usually diosgenin or its derivatives. Key saponins include: Let us separate the gym-bro lore from the

Slender, fibrous, light brown, and frequently branched. 2. Phytochemical Composition These are the primary active constituents responsible for

Tribulus terrestris may be considered a low-risk adjunct for mild erectile dysfunction or low libido in men without organic pathology, and as a diuretic/nephroprotective agent in recurrent urolithiasis. It is not a substitute for testosterone replacement therapy and should not be used for androgen deficiency without proper diagnosis.

A prospective study (n=56) using 500 mg extract twice daily for 6 months in patients with recurrent calcium oxalate stones showed significant reduction in stone recurrence and lower urinary calcium excretion compared to placebo (p<0.05).