Epic does not have a per-game toggle. You would need to disable cloud saves globally in the Launcher settings (Settings > Cloud Save > Disable).
The "Initialization Failed" error essentially means the game engine tried to read this file but couldn't. This usually happens for one of three reasons: Farming Simulator 22 Error Settings Initialization Failed
After updating, and try launching FS22.
Right-click the folder and select Properties . Uncheck the Read-only box at the bottom. Epic does not have a per-game toggle