Crossover is a polished, paid version of Wine that allows you to run Windows apps on macOS with high compatibility.
If you’re a Mac user and a fan of punishing roguelikes, you’ve likely run into the same question: Can I actually play The Binding of Isaac: Repentance on my Mac? The Binding Of Isaac Repentance Mac Download
The Binding of Isaac: Repentance is also available on the Epic Games Store, but the Mac support is historically less stable. As of 2025, it works, but updates arrive a few days later than Steam. Crossover is a polished, paid version of Wine
It’s free and specifically optimized for the latest versions of macOS (Sonoma and later). 3. Parallels Desktop As of 2025, it works, but updates arrive
| Problem | Solution | | :--- | :--- | | | Verify game files in Steam (Properties > Local Files > Verify integrity). | | “Missing Afterbirth+” error | Go to Steam DLC tab and ensure Afterbirth+ is installed. Uncheck and recheck it. | | Save file not transferring from PC | Use Steam Cloud Saves (enabled by default). If not, manually copy persistentgamedata1.dat from ~/Library/Application Support/Steam/userdata/[your ID]/250900/remote/ | | Controller not working | In Steam Big Picture Mode, go to Controller Settings and disable “Generic Gamepad Configuration Support”. Enable only PlayStation or Xbox support. | | Game is laggy on Intel Mac | Lower the “Render Scale” in Options from 200% to 100%. Turn off “Lighting Quality” and “Shockwave Effects”. |
For a Mac gamer, accessing this version is crucial, as the older versions ( Afterbirth+ ) no longer receive updates, and the active modding community is almost exclusively focused on Repentance .