Steam is a popular digital distribution platform that offers The Binding of Isaac for Mac. To download the game from Steam:

Rosetta 2 + Steam = solid performance. If you have an older Intel Mac on Catalina+: Consider using Whisky (free) to run the Windows version. If you have Mojave or older: You’re golden. Install and play directly.

: Requires a Mac with an Apple M1 chip or later and macOS 13.0 or later .

Method 1: The Best Free Option – Heroic Games Launcher & Wine

(commercial) and Wine (free, technical) can run the Windows version of Isaac on Mac with near-native performance.

Use CrossOver or Parallels to run the Windows version, granting you flawless mod compatibility and the original Flash experience via Ruffle.

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GOG (formerly Good Old Games) is another popular digital distribution platform that offers The Binding of Isaac for Mac. To download the game from GOG:

Buy The Binding of Isaac: Rebirth on Steam. If you have an M1 Mac or newer, add the Repentance DLC. This is the simplest, safest, and most reliable The Binding of Isaac Mac download available.