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| Stage | Neurobiological Change | Behavioral Manifestation | |-------|------------------------|--------------------------| | | Acute dopamine surge, heightened reward sensitivity | Craving, intense pleasure | | Withdrawal/Negative Affect | Dysregulation of stress systems (CRF, dynorphin) | Dysphoria, irritability | | Preoccupation/Anticipation | Strengthened cue‑reactivity, reduced prefrontal control | Persistent thoughts, compulsive seeking | If you are reading this because you typed
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